TRPV4 Rabbit Polyclonal Antibody

Description: A Rabbit Polyclonal antibody against TRPV4 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TRPV4 (Internal). This antibody is tested and proven to work in the following applications:

Description: Rabbit polyclonal TRPV4 antibody

Description: Purified Polyclonal TRPV4 antibody

Description: Rabbit polyclonal TRPV4 antibody raised against the middle region of TRPV4

Description: Rabbit polyclonal TRPV4 antibody raised against the middle region of TRPV4

Description: The transient receptor potential (TRP) protein family consists of a diverse group of cation channels functioning in a variety of homeostatic and regulatory pathways. Four subfamilies exist, based on channel domain homology: C type (canonical), V type (vanilloid receptor related), M type (melastatin related) and P type (PKD) (1). TRPV4, belongs to the V type subfamily and plays a role in systemic osmoregulation (2,3). TRPV4 is a calcium channel multi-pass membrane protein activated by various stimuli, including thermal stress, fatty acid metabolites and hypotonicity (3). TRPV4 is highly expressed in lung and kidney and widely expressed in brain. It plays an important role in regulating neural excitability (4).

Description: The transient receptor potential (TRP) protein family consists of a diverse group of cation channels functioning in a variety of homeostatic and regulatory pathways. Four subfamilies exist, based on channel domain homology: C type (canonical), V type (vanilloid receptor related), M type (melastatin related) and P type (PKD) (1). TRPV4, belongs to the V type subfamily and plays a role in systemic osmoregulation (2,3). TRPV4 is a calcium channel multi-pass membrane protein activated by various stimuli, including thermal stress, fatty acid metabolites and hypotonicity (3). TRPV4 is highly expressed in lung and kidney and widely expressed in brain. It plays an important role in regulating neural excitability (4).

Description: A polyclonal antibody against TRPV4. Recognizes TRPV4 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:10000, IHC:1:50-1:200

Description: A polyclonal antibody against TRPV4. Recognizes TRPV4 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Description: A polyclonal antibody against TRPV4. Recognizes TRPV4 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1:500-10000ELISA:1:10000

Description: A polyclonal antibody against TRPV4. Recognizes TRPV4 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:10000, IHC:1:50-1:200

Description: A polyclonal antibody against TRPV4. Recognizes TRPV4 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB

Description: A polyclonal antibody against TRPV4. Recognizes TRPV4 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000

Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TRPV4 (N-term). This antibody is tested and proven to work in the following applications:

Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TRPV4 (N-Terminus). This antibody is tested and proven to work in the following applications:

Description: The Anti Mouse TRPV4 Polyclonal Antibody is available in Europe and for worldwide shipping via Gentaur.

Description: Antibody raised against TRPV4

Description: Rabbit polyclonal to TRPV4.

Description: Rabbit polyclonal to TRPV4.

Description: This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene.

Description: (IN) TRPV4 Peptide

Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TRPV4 antibody, catalog no. 70R-5164

Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TRPV4 antibody, catalog no. 70R-5169

Description: A cloning plasmid for the TRPV4 gene.

Description: Description of target: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity (PubMed:11081638). Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification (PubMed:11081638). Also activated by heat, low pH, citrate and phorbol esters. Increase of intracellular Ca2+ potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Acts as a regulator of intracellular Ca2+ in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8. Together with PKD2, forms mechano- and thermosensitive channels in cilium. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes. Regulates expression of chemokines and cytokines related to proinflammatory pathway in adipocytes. Together with AQP5, controls regulatory volume decrease in salivary epithelial cells.;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sanadwich ELISA;Sensitivity: 5.8 pg/mL